NFL betting lines are tightening heading into Week 2, and the latest BET99 NFL odds feature a trio of exciting upcoming matchups. 

In the modern NFL, quarterbacks are kings. Just one non-QB has earned MVP in the last 20 years, and the 2026 season is unlikely to buck the trend with the 22 shortest odds all belonging to passers.  

Once more the lifeblood of their respective offenses, there are six tailbacks with odds of 10/1 or shorter to lead the league in rushing this season.